ABSTRACT
Objeetive To evaluate the efficacy of loratadine combined with de-escalation therapy for infant wheeze.Methods One hundred out-patients from Dec.2011 to Apr.2012 were randomly divided into 2 groups:Loratadine combined with de-escalation therapy was adopted in Loratadine group,while no Loratadine was taken in control group.The dose of Loratadine was 0.3 mL/(kg · d),14 days ; oral Prednisone 0.5 mg/(kg · d),3 days; Azithromycin 10 mg/(kg · d),3 days; Tulobuterol patch 0.5 mg/d,7 days; Montelukast 4 mg/d,14 days.Control group abolished Loratadine,but the rest of drugs were same as Loratadine group.Results The respiratory symptoms (gasp,wheeze sound,phlegm removal difficulty) and the nasal symptoms (including nasal congestion,sneeze,runny nose)in the acute phase of infant wheeze all had therapeutic effect,and there were significant differences in scoring symptoms (all P ＜ 0.05).The Loratadine group had certain treatment effect on eczema.The cough symptoms in 3 days,7days,14 days of the treatment had statistically significant differences between the both groups (all P ＜ 0.05).And there were statistical differences in eczema symptom of the Loratadine group in 7 days and 14 days of treatment (all P ＜ 0.05).Control group still had no statistical differences (all P ＞ 0.05).Days of improvement in symptoms,wheeze recurrence rate and frequency of respiratory infections in I month between 2 groups had no significant differences.Conclusions Loratadine can obviously improve the patients' breathing cough symptoms,and play a certain role in the treatment combined with de-escalation therapy in infant wheezing,and has high safety and eczema therapy effect.Loratadine can be used in clinic personally according to the patient's condition.